Lillian Hatton, Elliot Androphy, Anne Rietz

Spatial Transcriptomics Demonstrates Tissue-Specific Differential Gene Expression in a Mouse Model of Spinal Muscular Atrophy

Biomedical

Background: Spinal muscular atrophy (SMA) is an autosomal recessive disease resulting from insufficient survival motor neuron (SMN) protein that affli...

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Mae Shu, Mohammed Ghazali, Hannah Davis, Rohan Maniar, Patrick Loehrer

Optimizing CT Surveillance for Thymic Epithelial Tumors Based on Recurrence Characteristics

Medicine

Background: Thymic epithelial tumors (TETs), including thymoma and thymic carcinoma, are rare malignancies originating from the thymus gland epitheliu...

Review:

This study tackles a critical clinical need by aiming to optimize post-operative surveillance strategies for thymic epithelial tumors (TETs), a rare g...

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Angela Tang, Ho-Ching Yang, Yomna Takieldeen, Shannon Risacher, Andrew Saykin, Yu-Chien Wu

Relationship between Perivascular Space Burden, White Matter Hyperintensities, and Cognitive Function

Cognitive

Introduction: Perivascular space (PVS) is believed to be involved in clearing metabolic waste from the brain. PVS has been found to increase in size i...

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Jiayu Tian, Ivonne Cabrera, Chukwuebuka Ojukwu, Nicholas Harrison

Derivation of a Multivariable Model to Assist Emergency Department Triage of Heart Failure Patients by Their Diuretic Treatment Needs

Medicine

Background: Emergency medicine physicians (EMP) treat 1 million patients with acute decompensated heart failure (ADHF) annually. After emergency depar...

Review:

This paper addresses a significant challenge in emergency medicine: accurately triaging patients with acute decompensated heart failure (ADHF) based o...

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Alyssa Walker, Emily Seiden, Piper Wilburn, Ed Greenfield

Long Term Effects of Transient Romidepsin Exposure on Osteosarcoma Sarcospheres

Biomedical

Background:Osteosarcoma, the most prevalent primary bone cancer, disproportionally affects adolescents and young adults. Despite aggressive chemothera...

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Alexandra Cranston, Abigail Hall, Anushri Umesh, Nathan J. Alves

Exploring the Impact of Plasmin Inhibitors on Clotting Characteristics as a Novel Therapeutic for Thromboembolic Events

Biomedical

Background:Thromboembolisms are common, life-threatening emergencies. Systemic hemorrhaging post-thrombolytic treatment is an adverse reaction, highli...

Review:

This study introduces a compelling and potentially safer approach to treating thromboembolic events by investigating the co-delivery of plasmin and it...

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Joseph M. Dalloul, Devon Harvey, Jiannong Dai, Chenna Kesavulu Sugali, Weiming Mao

The Role of Cross-linked Actin Networks in the Proliferation and Senescence of Primary Human Trabecular Meshwork Cells

Biomedical

Purpose: TGFβ2 has been found to be elevated in the trabecular meshwork (TM) of patients with primary open-angle glaucoma. TM cells treated with TGFβ2...

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Benjamin Holland, Mayra Kotlik, Kathryn Lowe, Samantha Wallace, Anna Latimer, Danielle Soranno, Cara Slagle, Michelle Starr

Clinical Impact and Sustainability of a Standardized Neonatal Nephrology Consult Program

Medicine

Background/Objective: Acute kidney injury (AKI) is common in high-risk neonates and is associated with increased morbidity and mortality. Standardized...

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Nathan Hubbard, Shahna Shahul Hameed, Tasneem Sharma

Determining the Therapeutic Effect of Human Neuritin 1 on the Restoration of Degenerated Retinal Ganglion Cells from Glaucoma Patients

Neuroscience

Background and Hypothesis: Glaucoma is a group of optic neuropathies that affects approximately 76 million people worldwide. The main risk factor is e...

Review:

This study addresses a critical unmet need in glaucoma treatment by exploring novel strategies for the regeneration and protection of retinal ganglion...

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Jared Clark, Andreia Alexander

Evaluation of Resident Presentations Using a DEI Checklist

Evaluation

Background: In 2021, the Indiana University School of Medicine Department of Emergency Medicine developed a DEI checklist for residents presenting to...

Review:

This study presents a timely and important evaluation of a DEI checklist implemented for resident presentations within an Emergency Medicine departmen...

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