Isaias Colon, Angelique Wise, Jenifer Prosperi

Sensitization of APC knock-out cells to Doxorubicin in vitro using KU55933, an ATM inhibitor

Biomedical

Background and Hypothesis: Triple negative breast cancer (TNBC) has the lowest 5-year survival rate among breast cancer subtypes, with Adenomatous P...

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Om Dalal, Lauren Maldonado, Gertrude Anusu, Laura Ruhl, Maureen Chepkoech, Anjellah Jumah, Joan Keter, Justus Elung’at, Michael Scanlon, Astrid Chrisoffersen-Deb, Edith Apondi, Julia Songok, Julie Thorne

Assessing a Community-based, Group Care Program Adapted for Pregnant and Parenting Adolescents in Western Kenya: An Acceptability and Feasibility Study

Health

Background: An estimated 21 million adolescent pregnancies occur worldwide, predominantly in low- and middle-income countries (LMICs). These pregnanci...

Review:

This timely study addresses the critical global challenge of adolescent pregnancies, particularly in low- and middle-income countries, where poor heal...

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Gloria V. Cabrero, LaKeisha Boyd, Deanna Reinoso, Richard J. Holden, Daniel O. Clark, Titus K. Schleyer, Rebecca L. Rivera

FoodRx: Exploring Disparities in Food Insecurity and Eye Health Conditions

Health

Background: Good nutrition and chronic disease management are important for eye health; however, little is known about the relationship between food i...

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Neon Calumpang, Jonathan Guerrero, Kyle Gospodarek

Demographic, Social, and Behavioral Predictors of Readmission for Neurodegenerative Diseases in Northwest Indiana

Health

Background: Neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, pose significant challenges given their progressive nature and mu...

Review:

This study addresses a critically important area concerning hospital readmissions among individuals with neurodegenerative diseases, a population with...

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Anslyn Freije, Melissa Abt, Tinslee Dilday, Elizabeth Yeh

Validation of Rubicon's Autophagy Inhibition Function Through HUNK Phosphorylation

Biomedical

Background and Hypothesis: HER2+ breast cancer uses the human epidermal growth receptor 2 (HER2) protein to grow. As an aggressive form of breast canc...

Review:

This abstract presents a compelling hypothesis regarding the role of HUNK phosphorylation in regulating Rubicon's autophagy inhibition function, parti...

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Kyle Richardson, Anika Shimonty, Joshua Huot, Fabrizio Pin, Lynda F. Bonewald

Sex-Dependent Effects of Irisin on Bone in an Aged Mouse Model

Biomedical

Irisin is a recently discovered protein that has garnered increasing attention due to its potential impact on metabolic health and disease prevention....

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Elizabeth Roy, Victor Olafusi, Enaja Sambatur, Faezeh Aghajani, Moti Gulersen, Asma Khalil, Vincenzo Berghella, Hiba J. Mustafa

Late Antenatal Corticosteroid Treatment in Twin Pregnancies and Neonatal Outcomes: A Systematic Review and Meta-Analysis

Medicine

Objective: To examine the impact of administering late-preterm corticosteroids on neonatal outcomes in twin pregnancies.  Study Design: A systema...

Review:

This systematic review and meta-analysis addresses a clinically pertinent question regarding the efficacy and safety of late-preterm antenatal cortico...

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Susie Kim, Mark Fox, Heidi Beldinger-Burnett

Implementation of Indiana’s Universal Blood Lead Testing Mandate: Interviews with Primary Care Practices in Michiana

Administration

Background: Disparities in lead exposure and social determinants of health – including housing, environmental conditions, and nutrition security – inf...

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Nathan Fuchs, Hallel Paraiso, Hannah Huang, I-Chen Ivorine Yu

Analysis of Cerebral Small Vessel Changes in an APOE4 Knock-In AD Mouse Model

Neuroscience

Introduction:  Alzheimer’s disease (AD) is a complex neurodegenerative disorder and the leading cause of dementia worldwide.  Recently appro...

Review:

This study addresses a highly relevant and timely topic in Alzheimer's disease research: the differential impact of APOE4 on cerebral small vessels. G...

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Alison Blodgett, Jonathan Guerrero, Baraka Muvuka

Food Insecurity: An Upstream Social Determinant of 30-Day Congestive Heart Failure Readmissions

Health

Background:   Approximately 6.7 million Americans have congestive heart failure (CHF), costing the healthcare system over $30 billion annual...

Review:

This study tackles a highly pertinent issue in healthcare: the significant burden and cost associated with 30-day congestive heart failure (CHF) readm...

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