Devortivo Hartono Putra, Erida Novriani, Razoki

Uji Anti Hiperglikemik Ekstrak Etanol Daun Salam (Syzygium Polyanthum (Wight.) Walp) Dan Daun Cepcepan (Castanopsis Costata (Blume) A. Dc.) Terhadap Tikus Putih

Introduction

Uji anti hiperglikemik ekstrak etanol daun salam (syzygium polyanthum (wight.) walp) dan daun cepcepan (castanopsis costata (blume) a. Dc.) terhadap tikus putih. Penelitian uji anti hiperglikemik ekstrak etanol kombinasi daun salam dan cepcepan pada tikus diabetes. Menunjukkan potensi menurunkan gula darah sebagai terapi alternatif.

Abstract

Hyperglycemia, characterized by elevated blood glucose levels, is a key clinical feature of diabetes mellitus. In recent years, medicinal plants have gained attention as alternative therapies due to their relatively minimal side effects. This study aimed to explore the potential of acombined ethanol extract of bay leaf (Syzgium polyanthum) and cepcepan leaf (castanopsis costata) in lowering blood flucose leveles in white rats (Rattus norvegicus) induced with alloxan. The extraction process was carried out using the maceration methos with 96% ethanol. Phytochemical screening revealed the presence of active compounds such as flavonoids, alkoloids, tannins, saponins, and steroid. The rats were divided into six groups: a normal group. A negative control group (alloxan only), a positive control group (glibenclamide 0.45 mg/kgBB), and three treatment groups receiving the combined extract at doses of 120 mg/kgBW, 250mg/kgBW, and 500mg/kgBW. Blood glucose levels were monitored from day 0 to day 15. ANOVA analysis showed a reduction in glucose levels among the treatment groups, althought the results were not statistically significant (p > 0.05). nevertheless, a consistent downward trend was observed, particularyl in the group receiving 250mg/kgBW. These findings suggest that the  ethanol extract combination of bay and cepcepan leaves holds promise as an antihyperlycemic agent. However, frurther research is necessary to confirm its efficacy and fully understand its mechanism of action.

Review

This study addresses a highly relevant issue concerning the management of hyperglycemia in diabetes mellitus, investigating the potential of a combined ethanol extract from *Syzgium polyanthum* (bay leaf) and *Castanopsis costata* (cepcepan leaf). The rationale for exploring medicinal plants as alternative therapies, particularly those with a history of traditional use and potentially fewer side effects, is well-justified. The research effectively outlines a clear objective: to assess the antihyperglycemic activity of this specific combined extract in alloxan-induced white rats. The initial steps, including the maceration extraction method and preliminary phytochemical screening, which identified a range of active compounds such as flavonoids, alkaloids, tannins, saponins, and steroids, lay a foundational basis for the observed biological activities. The experimental design is appropriately structured with normal, negative, and positive control groups, alongside three distinct treatment doses of the combined extract (120, 250, and 500 mg/kgBW). Blood glucose levels were monitored over a 15-day period, providing a reasonable timeframe for observing acute effects. While the study reports a "reduction in glucose levels" within the treatment groups and highlights a "consistent downward trend," particularly in the 250 mg/kgBW group, the crucial finding is that the ANOVA analysis did *not* yield statistically significant results (p > 0.05). This lack of statistical significance is a critical point that tempers the observed trends, suggesting that while there might be an effect, the current experimental parameters were insufficient to confidently differentiate it from random variation. Despite the non-significant statistical outcome, the consistent downward trend observed, especially at the 250 mg/kgBW dose, suggests that the combined extract might indeed possess some antihyperglycemic potential. However, to transition from promising trends to conclusive evidence, further rigorous investigation is essential. Future research should consider extending the study duration, increasing the sample size per group, and potentially refining the dosage regimen to optimize efficacy and achieve statistical significance. Moreover, a deeper dive into the mechanism of action, possibly isolating and testing specific active compounds identified in the phytochemical screening, would significantly enhance the understanding of how these extracts exert their effects. This would strengthen the scientific basis for their potential use as an adjunctive or alternative therapy.

Full Text

Comments

You need to be logged in to post a comment.