Yonatan, Suryani Dyah Astuti, Khusnul Ain, Deni Arifianto, Ahmad Khalil Yaqubi

THE EFFECT OF LED MAGNETIC ON STAPHYLOCOCCUS AUREUS BACTERIA

Introduction

The effect of led magnetic on staphylococcus aureus bacteria. Explore LED magnetic field efficacy in inactivating Staphylococcus aureus bacteria. Crucial for reducing nosocomial infections, achieving up to 81.92% bacterial reduction.

Abstract

Nosocomial infections, caused by viruses, bacteria, and fungal pathogens, often occur during treatment in health facilities due to cross-contamination from healthcare workers or medical equipment. The study explores the efficacy of static magnetic fields and photodynamic inactivation in inactivating Staphylococcus aureus bacteria, a crucial step in sterilization. The study used high-power blue LEDs and static magnetic fields generated by neodymium magnets. The highest reduction percentage observed was 81.92 ± 7.92%, found in the combination treatment of static magnetic fields (SMF) with LED illumination at the F8 microplate location, with a treatment time of 40 minutes, an LED dose of 11.72 J/cm², and a magnetic field dose of 25.61 mT. The lowest reduction percentage, 52.41 ± 7.64%, was observed at the F8 microplate location with a treatment time of 10 minutes, an LED dose of 2.93 J/cm², and a magnetic field dose of 25.61 mT.

Review

This paper addresses a highly relevant issue within public health, focusing on novel methods to combat nosocomial infections, particularly those caused by *Staphylococcus aureus*. The increasing challenge of antibiotic resistance makes the exploration of non-pharmacological sterilization and decontamination techniques, such as those employing physical modalities, critically important. The study introduces an intriguing dual-modality approach, investigating the combined efficacy of static magnetic fields (SMF) and photodynamic inactivation (PDI) using blue LEDs, offering a promising avenue for enhancing sterilization strategies in healthcare settings. The methodology deployed involved the application of high-power blue LEDs in conjunction with static magnetic fields generated by neodymium magnets against *S. aureus* bacteria. The abstract reports a significant and dose-dependent bacterial reduction. The most effective treatment, a combination of SMF and LED illumination, achieved an 81.92 ± 7.92% reduction of *S. aureus* after 40 minutes of exposure, utilizing an LED dose of 11.72 J/cm² and a magnetic field dose of 25.61 mT. Even under less intensive conditions—10 minutes of treatment with an LED dose of 2.93 J/cm² and the same magnetic field dose—a substantial 52.41 ± 7.64% reduction was observed, underscoring the potential of this combined approach. Overall, the findings provide a compelling preliminary demonstration of the antimicrobial potential of combining static magnetic fields with blue LED illumination against *Staphylococcus aureus*. While the reported reduction percentages are encouraging for a physical inactivation method, a deeper mechanistic understanding of how SMF interacts with bacterial cells and how it synergizes with blue light-mediated inactivation would significantly enhance the paper's scientific impact. Future research should aim to optimize treatment parameters across a broader spectrum, investigate the method's efficacy against other clinically relevant pathogens, and explore its practical applicability for sterilizing medical devices or decontaminating surfaces in a clinical context. Further clarification regarding the specific role of "photodynamic inactivation" if no exogenous photosensitizer is employed, and the significance of the "F8 microplate location," would also benefit the clarity and comprehensiveness of the work.

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