Sarmoko Sarmoko, Riri Fauziyya, Miralda Zahra, Nisa Yulianti Suprahman, Winni Nur Auli, Arif Ashari

RECENT UPDATE OF ZERUMBONE AS ANTI-COLON CANCER AGENT: A REVIEW

Introduction

Recent update of zerumbone as anti-colon cancer agent: a review. Zerumbone shows promise as an anti-colorectal cancer agent. This review details its mechanisms: apoptosis, metastasis inhibition, gut microbiota modulation, and its potential for CRC therapy.

Abstract

Colorectal cancer (CRC) remains a leading cause of cancer-related deaths worldwide, with limited effective therapies due to drug resistance and adverse effects. Zerumbone, a sesquiterpene isolated from Zingiber zerumbet Smith, has emerged as a promising natural anticancer agent. This review examines zerumbone's anti-colorectal cancer properties, including induction of apoptosis and cell cycle arrest, inhibition of invasion and metastasis, anti-angiogenic activity, and anti-inflammatory effects. Additionally, zerumbone demonstrates antioxidant properties, modulates gut microbiota composition, and targets multiple signaling pathways involved in CRC pathogenesis. Structure-activity relationship studies reveal the critical role of the α,β-unsaturated carbonyl group in its bioactivity. Despite promising preclinical evidence, clinical validation remains necessary to establish zerumbone's therapeutic potential for colorectal cancer management.

Full Text

Comments

You need to be logged in to post a comment.