Florence Meliawaty, Mistli Nur Robbani , Hartanto Endrowahyudi, Euis Reni Yuslianti

PROSPECTIVE USE OF REUNDEU LEAVES (Staurogyne elongata) ON INFLAMMATORY MACROPHAGES IN SKIN EXCISION WOUND

Introduction

Prospective use of reundeu leaves (staurogyne elongata) on inflammatory macrophages in skin excision wound. Reundeu leaves (Staurogyne elongata) show promise for skin wound healing. It modulates inflammatory macrophages, reducing inflammation & promoting tissue regeneration naturally.

Abstract

Healing of skin excision wounds involves complex stages, with inflammatory macrophages playing a key role in regulating the inflammatory response and tissue regeneration. Staurogyne elongata (Reundeu leaves), a medicinal plant native to Indonesia, contains bioactive compounds such as flavonoids, saponins, steroids, triterpenoids, and polyphenols, which exhibit antioxidant and antibacterial properties. This literature review aimed to explore the prospective role of S. elongata in modulating inflammatory macrophage activity during skin excision wound healing. Articles published within the last 10 years were retrieved from ProQuest, PubMed, ScienceDirect, and Science Publishing Group databases. The scientific implication is that Staurogyne elongata (Reundeu leaves) has potential therapeutic effects on skin excision wound healing by modulating inflammatory macrophage activity. Specifically, its bioactive compounds may promote the transition of macrophages from a pro-inflammatory (M1) to an anti-inflammatory (M2) state, leading to reduced inflammation and enhanced tissue regeneration. The results suggest that S. elongata could be developed as a natural, cost-effective adjunct treatment to improve wound healing outcomes, highlighting the need for further experimental validation, clinical studies, and pharmaceutical formulation development. DOI : 10.54052/jhds.v5n2.p213-226

Review

This literature review effectively addresses a critical aspect of wound healing by investigating the prospective role of *Staurogyne elongata* (Reundeu leaves) in modulating inflammatory macrophage activity. The authors frame the discussion around the complex stages of skin excision wound healing, where inflammatory macrophages play a pivotal role in regulating both inflammation and tissue regeneration, thereby establishing a strong rationale for exploring natural compounds. The focus on an Indonesian medicinal plant, known for its rich profile of bioactive compounds such as flavonoids, saponins, steroids, triterpenoids, and polyphenols with documented antioxidant and antibacterial properties, is particularly relevant for identifying novel and potentially cost-effective therapeutic agents for wound management. The methodology, involving a systematic retrieval of articles from established databases within the last decade, provides a solid foundation for their prospective analysis. The core scientific implication derived from this review lies in the proposed mechanism by which *S. elongata* may exert its therapeutic effects on wound healing. The authors compellingly suggest that the aforementioned bioactive compounds could promote the crucial transition of macrophages from a pro-inflammatory (M1) to an anti-inflammatory (M2) state. This modulation is hypothesized to lead to a significant reduction in inflammation and a concomitant enhancement of tissue regeneration, positioning *S. elongata* as a promising natural adjunct treatment for improving wound healing outcomes. This theoretical framework provides a clear direction for future research, highlighting a specific cellular mechanism that could be targeted by plant-derived compounds. While this literature review successfully highlights the significant potential of *Staurogyne elongata*, it appropriately acknowledges its limitations as a review-based study. The authors explicitly call for further experimental validation, rigorous clinical studies, and dedicated pharmaceutical formulation development, which are essential steps before its translation into practical application. This forward-looking perspective, coupled with the prospect of a natural and cost-effective treatment to improve wound healing, underscores the scientific implication and value of this preliminary exploration. The review serves as an important foundational piece, effectively compiling existing knowledge and setting a clear agenda for subsequent investigative work in the field of wound healing ethnopharmacology.

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