Rini Puspita Sari, Morita Sari, Ariyani Faizah, Cahyani

POTENTIAL ROLE OF L – ARGININE IN SESAME SEEDS FOR DENTAL CARIES PREVENTION

Introduction

Potential role of l – arginine in sesame seeds for dental caries prevention. Discover the potential of L-arginine in sesame seeds for dental caries prevention. This review evaluates its role in inhibiting caries pathogenesis and reducing oral sensitivity.

Abstract

Dental caries is a chronic disease caused by damage to tooth enamel. The epidemiology of the prevalence of dental caries in Indonesia is 88.80%. Some cases are detected in more severe conditions that involve pulp damage. L-arginine is one of the substances that can prevent and inhibit the progression of dental caries pathogenesis. However, few studies have discussed the role of L-arginine. This literature review aims to evaluate the potential role of L-arginine in preventing dental caries. The research uses a systematic review approach on various databases, namely PubMed, Scopus and Web of Science published in the range of 2021 – 2025. Results: After the selection, as well as the screening of articles, 5 RCT articles were found, and 4 review articles were found in accordance with the research objectives. Most studies had observational analysis outputs less 1 year so they did not show long-term results, as well as side effects of L-arginine use. L-arginine can inhibit the progression of pathogenesis of dental caries disease, as well as reduce sensitivity symptoms in the oral cavity. DOI : 10.54052/jhds.v5n2.p151-162

Review

This literature review addresses a highly pertinent topic in preventive dentistry, investigating the potential role of L-arginine in mitigating dental caries, a widespread chronic disease. The authors employ a systematic review approach, synthesizing findings from PubMed, Scopus, and Web of Science databases from 2021 to 2025, which provides a current snapshot of the research landscape. The review's objective to evaluate L-arginine's potential is well-articulated, and the identification of 5 RCTs and 4 review articles suggests a reasonable body of recent literature for analysis. The conclusion that L-arginine can inhibit caries progression and reduce oral sensitivity symptoms offers a valuable synthesis for clinicians and researchers. However, a significant discrepancy arises between the title and the abstract's content. The title, "POTENTIAL ROLE OF L – ARGININE IN SESAME SEEDS FOR DENTAL CARIES PREVENTION," explicitly limits the scope to L-arginine *in sesame seeds*. Yet, the abstract discusses L-arginine generally, without any further mention of sesame seeds, its extraction, delivery, or specific properties related to this source. This omission suggests either a misrepresentation in the title or a failure to execute the specific scope implied. Furthermore, the abstract itself identifies a critical limitation of the included studies: most had observational analysis outputs of less than one year, thereby failing to demonstrate long-term efficacy or potential side effects of L-arginine use. This highlights a crucial gap in the current evidence base that the review appropriately points out. Despite these limitations, the review serves as a useful aggregation of recent evidence on L-arginine's promise in dental health. Future iterations or subsequent research stemming from this review would benefit greatly from clarifying the intended scope regarding sesame seeds. If the focus is indeed on L-arginine from this specific source, the methodology should explicitly detail how studies related to "sesame seed L-arginine" were identified and analyzed, or the title should be adjusted to reflect a broader scope of L-arginine. The identified lack of long-term studies also underscores an urgent need for robust, extended-duration clinical trials to establish definitive efficacy, optimal dosages, and safety profiles for L-arginine in caries prevention.

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