Mei Lisa, Lipinwati Lipinwati, Attiya Istarini, Ahmad Syauqy, Nyimas Natasha Ayu Shafira

HUBUNGAN KADAR GULA DARAH SEWAKTU DENGAN NEUROPATI DIABETIK PADA PASIEN DIABETES MELITUS TIPE 2

Introduction

Hubungan kadar gula darah sewaktu dengan neuropati diabetik pada pasien diabetes melitus tipe 2. Studi ini mengungkap hubungan signifikan kadar gula darah sewaktu dengan neuropati diabetik pada pasien diabetes melitus tipe 2. Pahami risiko dan pencegahannya.

Abstract

ABSTRAK Pendahuluan: Diabetes melitus dapat menyebabkan komplikasi mikrovaskular, salah satunya adalah neuropati, yang dipicu oleh hiperglikemia persisten. Tujuan: Mengetahui hubungan antara kadar gula darah sewaktu dan kejadian neuropati diabetik pada pasien diabetes melitus tipe 2. Metode: Penelitian observasional analitik dengan desain cross-sectional, melibatkan 92 pasien diabetes melitus tipe 2. Neuropati dinilai menggunakan DNS-Ina, sedangkan kadar gula darah diperoleh dari pemeriksaan laboratorium. Analisis data dilakukan dengan uji Chi-square. Hasil: Sebanyak 53,3% responden tidak mengalami hiperglikemia, sementara 82,3% mengalami neuropati diabetik. Uji Chi-square menunjukkan nilai p 0.017 dengan rasio odds 4.568, yang mengindikasikan hubungan signifikan antara kadar gula darah sewaktu dan neuropati diabetik. Kesimpulan: Terdapat hubungan signifikan antara kadar gula darah sewaktu dengan kejadian neuropati diabetik pada pasien diabetes melitus tipe 2 di RSUD H. Abdul Manap Kota Jambi. Kata kunci: Neuropati diabetik, gula darah sewaktu, diabetes melitus tipe 2

Review

This study addresses a clinically crucial topic: the relationship between random blood glucose levels and diabetic neuropathy in Type 2 Diabetes Mellitus (T2DM) patients. Given the high global prevalence of T2DM and its debilitating complications, understanding factors contributing to diabetic neuropathy is paramount for effective patient management and prevention. The authors aimed to identify this relationship in a cohort of T2DM patients, utilizing a cross-sectional design, and found a significant association, contributing valuable local data from the RSUD H. Abdul Manap Kota Jambi. The methodology employed was an observational analytic cross-sectional study involving 92 patients, a reasonable sample size for this type of investigation. Neuropathy assessment using DNS-Ina and random blood glucose measurements from laboratory tests provided objective data. A notable finding was the high prevalence of diabetic neuropathy (82.3%) even among respondents who did not exhibit hyperglycemia at the time of the random blood sugar test (53.3%). The Chi-square test revealed a statistically significant relationship (p=0.017) with an odds ratio of 4.568, indicating that patients with higher random blood glucose levels were significantly more likely to experience diabetic neuropathy. This highlights the immediate clinical relevance of monitoring blood glucose in T2DM patients to mitigate neuropathy risk. While the study provides compelling evidence for an association, it is important to acknowledge the limitations inherent in its cross-sectional design. This design allows for the identification of associations but cannot definitively establish causality between random blood glucose and the development of neuropathy. Furthermore, the reliance on "kadar gula darah sewaktu" (random blood sugar) provides only a snapshot of glycemic control, which may not fully reflect the persistent hyperglycemia known to drive chronic complications like neuropathy. Future research would benefit from incorporating long-term glycemic control markers, such as HbA1c, and employing longitudinal designs to track the progression of neuropathy in relation to sustained glycemic management. Despite these limitations, the paper offers important insights into the local burden of diabetic neuropathy and its immediate correlation with random blood glucose levels.

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