Proceedings of IMPRS
Research
Explore the scientific proceedings of the International Max Planck Research School (IMPRS). Discover cutting-edge research, academic papers, and key findings.
Articles in this Journal
UGT2B10 Variant Effects on Dexmedetomidine Metabolism Using Nicotine Studies
Background:Dexmedetomidine is a procedural sedative primarily metabolized by the UDP-glucuronosyltransferase (UGT) 2B10. UGT2B10 also contributes to nicotine metabolism. Most research on the effect of gene variants on UGT2B10’s glucuronidation effica...
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Light-Dependent Structural Changes in Photoreceptor Neurons Imaged by OCT
Background: Optical coherence tomography (OCT) is an imaging technique with high spatiotemporal resolution used to monitor the retina, photoreceptor degeneration, and potentially the visual cycle. In this study, we aim to examine how various light co...
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Sensitization of APC knock-out cells to Doxorubicin in vitro using KU55933, an ATM inhibitor
Background and Hypothesis: Triple negative breast cancer (TNBC) has the lowest 5-year survival rate among breast cancer subtypes, with Adenomatous Polyposis Coli (APC) mutations/deletions found to be a leading cause of Doxorubicin (DOX) resistance....
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Assessing a Community-based, Group Care Program Adapted for Pregnant and Parenting Adolescents in Western Kenya: An Acceptability and Feasibility Study
Background: An estimated 21 million adolescent pregnancies occur worldwide, predominantly in low- and middle-income countries (LMICs). These pregnancies often result in poor health outcomes due to low health literacy and limited healthcare interactio...
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FoodRx: Exploring Disparities in Food Insecurity and Eye Health Conditions
Background: Good nutrition and chronic disease management are important for eye health; however, little is known about the relationship between food insecurity and eye health outcomes. Marion County is designated as a medically underserved area, and...
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Demographic, Social, and Behavioral Predictors of Readmission for Neurodegenerative Diseases in Northwest Indiana
Background: Neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, pose significant challenges given their progressive nature and multifaceted care needs. This research examined the intricate interplay between social determinants of...
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Validation of Rubicon's Autophagy Inhibition Function Through HUNK Phosphorylation
Background and Hypothesis: HER2+ breast cancer uses the human epidermal growth receptor 2 (HER2) protein to grow. As an aggressive form of breast cancer, it accounts for ~20% of all breast cancer diagnoses worldwide. Previous studies show Hormonally...
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Sex-Dependent Effects of Irisin on Bone in an Aged Mouse Model
Irisin is a recently discovered protein that has garnered increasing attention due to its potential impact on metabolic health and disease prevention. This hormone, released from exercising skeletal muscle, is generated through the cleavage of the me...
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Late Antenatal Corticosteroid Treatment in Twin Pregnancies and Neonatal Outcomes: A Systematic Review and Meta-Analysis
Objective: To examine the impact of administering late-preterm corticosteroids on neonatal outcomes in twin pregnancies. Study Design: A systematic review of the literature was conducted in four electronic databases between 2000-2024. Studies r...
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Implementation of Indiana’s Universal Blood Lead Testing Mandate: Interviews with Primary Care Practices in Michiana
Background: Disparities in lead exposure and social determinants of health – including housing, environmental conditions, and nutrition security – influence developmental and health outcomes, plus academic achievement and socioeconomic status through...
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Analysis of Cerebral Small Vessel Changes in an APOE4 Knock-In AD Mouse Model
Introduction: Alzheimer’s disease (AD) is a complex neurodegenerative disorder and the leading cause of dementia worldwide. Recently approved monoclonal antibody therapy has shown increased instances of amyloid-related imaging abnormaliti...
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Food Insecurity: An Upstream Social Determinant of 30-Day Congestive Heart Failure Readmissions
Background: Approximately 6.7 million Americans have congestive heart failure (CHF), costing the healthcare system over $30 billion annually. Readmissions contribute significantly to these costs, as 20-25% of hospitalized CHF patients are...
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Spatial Transcriptomics Demonstrates Tissue-Specific Differential Gene Expression in a Mouse Model of Spinal Muscular Atrophy
Background: Spinal muscular atrophy (SMA) is an autosomal recessive disease resulting from insufficient survival motor neuron (SMN) protein that afflicts ~1 in 10,000 births. Motoneurons are specifically sensitive to low SMN levels and motoneuron dea...
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Optimizing CT Surveillance for Thymic Epithelial Tumors Based on Recurrence Characteristics
Background: Thymic epithelial tumors (TETs), including thymoma and thymic carcinoma, are rare malignancies originating from the thymus gland epithelium. Surgery is the primary treatment for early-stage disease, and post-operative surveillance is cruc...
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Relationship between Perivascular Space Burden, White Matter Hyperintensities, and Cognitive Function
Introduction: Perivascular space (PVS) is believed to be involved in clearing metabolic waste from the brain. PVS has been found to increase in size in patients with Alzheimer’s disease, but the relationship between PVS enlargement and cognitive func...
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