Nur Sifatullah, Zulkarnain Zulkarnain

Jerawat (Acne vulgaris): Review penyakit infeksi pada kulit

Introduction

Jerawat (acne vulgaris): review penyakit infeksi pada kulit. Pelajari Jerawat (Acne vulgaris), penyakit infeksi kulit umum. Pahami penyebab, mekanisme patogenesis seperti sebum berlebih & bakteri P. acnes, serta metode pengobatannya. Review komprehensif.

Abstract

Kulit merupakan lapisan jaringan yang menyebar di seluruh permukaan tubuh. Di permukaan kulit, kelenjar keringat mengeluarkan produk limbah melalui pori-pori kulit berupa keringat. Jerawat (Acne vulgaris) merupakan suatu kondisi dimana pori-pori tersumbat dan menyebabkan kantong nanah menjadi meradang. Penyebab pasti dan patogenesis A. vulgaris masih belum jelas. Namun, banyak faktor yang berhubungan dengan patogenesis jerawat, seperti peningkatan sekresi sebum, hiperkeratosis folikel rambut dan koloni bakteri Propionibacterium acnes, dan inflamsi serta faktor lain yaitu stres, iklim/suhu/kelembaban, kosmetik, diet dan obat-obatan. Acne vulgaris dipicu oleh P. acnes pada masa remaja, di bawah pengaruh sirkulasi normal dehydroepiandrosterone (DHEA). Mekanisme pembentukan jerawat (A. vulgaris), yaitu stimulasi pada kelenjar sebasea yang menyebabkan sebum berlebih biasanya dimulai pada masa puberta, proliferasi keratinosit yang abnormal, adhesi dan diferensiasi cabang bawah folikel folikel, dan pembentukan lesi inflamasi berperan pada bakteri P. acnes. Pengobatan jerawat (A. vulgaris) dilakukan dengan cara memperbaiki folikel yang abnormal, mengurangi produksi sebum, mengurangi jumlah koloni P. acnes atau hasil metaboliknya, dan mengurangi peradangan pada kulit.

Review

The review titled "Jerawat (Acne vulgaris): Review penyakit infeksi pada kulit" aims to provide an overview of acne vulgaris. The abstract outlines a comprehensive scope, defining acne as a condition involving clogged pores and inflamed pustules, and detailing numerous contributing factors. These include well-established elements like increased sebum production, follicular hyperkeratosis, and the role of *Propionibacterium acnes*, alongside other influential factors such as stress, climate, cosmetics, diet, and medication. The abstract also sketches the mechanistic steps of acne formation, from sebaceous gland stimulation to inflammatory lesion development, and lists the primary goals of treatment. A strength of this abstract is its broad coverage, encompassing both internal physiological processes and external environmental triggers, thus providing a holistic perspective on acne pathogenesis. It effectively summarizes the multi-factorial nature of the disease and outlines common treatment strategies aimed at correcting follicular abnormalities, reducing sebum, targeting *P. acnes*, and mitigating inflammation. However, the abstract presents a minor inconsistency by stating "Penyebab pasti dan patogenesis A. vulgaris masih belum jelas" immediately before detailing a clear mechanism of formation. More significantly, the title classifies acne as an "infectious disease," a framing that the abstract, while mentioning *P. acnes*, does not fully substantiate as the primary defining characteristic of acne's etiology, given the equal emphasis on sebaceous activity, hyperkeratosis, and hormonal influences. This particular framing might require stronger justification or a more nuanced discussion in the full review. Overall, the abstract suggests that the full review will serve as a valuable general reference, compiling a range of information pertinent to acne vulgaris. For the paper to truly excel, especially given its title, the authors should clearly articulate the specific angle or novelty of their "infectious disease" perspective. This could involve a deeper exploration of bacterial involvement beyond mere colonization, perhaps discussing specific virulence factors or host immune responses to *P. acnes* that align with a disease classification as primarily infectious. Clarifying the interplay between bacterial presence and other non-infectious pathogenic factors would strengthen the review's coherence and academic impact. As it stands, the abstract promises a comprehensive, albeit somewhat conventional, summary of acne vulgaris, which could be particularly useful for students or general practitioners seeking a broad introductory text.

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