Marvi, kashif Iqbal, Arooj Mohsin Alvi, Maryum Mumshad Raja, Hassan Irfan, Ayesha Sana, Ayaz Ali Khan, Amanullah Sial

EVALUATION OF ANALGESIC AND ANXIOLYTIC EFFECTS OF PEROVSKIA ABROTANOIDES IN SWISS ALBINO MICE

Introduction

Evaluation of analgesic and anxiolytic effects of perovskia abrotanoides in swiss albino mice . Explore Perovskia abrotanoides' analgesic & anxiolytic properties in Swiss albino mice. Discover its safe, natural potential for pain, anxiety, and depression relief, comparable to aspirin.

Abstract

Background: Perovskia abrotanoides is a shrubby plant from a lesser-known genus within the Lamiaceae family, reputed for its notable medicinal qualities. It has been traditionally used for the treatment of liver problems, respiratory disorders, and several other illnesses. However, its analgesic and anxiolytic effects still need further exploration. Objectives: This research provides a thorough investigation into the analgesic and anxiolytic potential of Perovskia abrotanoides, commonly used due to its medicinal benefits. Methodology: Perovskia abrotanoides methanolic extract was subjected to an acute toxicity test to analyze the safety of Perovskia abrotanoides methanolic extract. Acute toxicity of the methanolic extract was evaluated in 25 male Swiss albino mice at dosages ranging from 250 to 2000 mg/kg. The analgesic efficacy of Perovskia abrotanoides methanolic extract was assessed through the acetic acid-induced writhing and formalin tests. The anxiolytic effect of Perovskia abrotanoides methanolic extract was evaluated through behavioural assessments, including the open field test, cage crossing test, rearing test, traction test, and forced swim test. Results: Acute toxicity studies indicated safe administration of Perovskia abrotanoides methanolic extract at 250-2000 mg/kg dose. Moreover, it exhibited a substantial analgesic effect, as evaluated through pain relief, comparable to that of aspirin. Additionally, mice administered Perovskia abrotanoides methanolic extract exhibited enhanced exploratory behavior and reduced immobility time, suggesting potential antidepressant-like properties. Conclusion: This research highlights the safety and therapeutic potential of Perovskia abrotanoides as a natural remedy for anxiety, depression, and pain, underscoring that its methanolic extract possesses significant analgesic and anxiolytic properties attributed to its bioactive components, which modulate inflammatory pathways and alleviate oxidative stress

Review

This study presents a compelling investigation into the analgesic and anxiolytic potential of *Perovskia abrotanoides*, a traditionally recognized medicinal plant. The research effectively addresses a significant gap by scientifically validating its purported therapeutic effects beyond its traditional uses for liver and respiratory issues. The objectives are clearly articulated, and the rationale for exploring natural remedies for pain, anxiety, and depression is highly pertinent given the global health burden and side-effect profiles associated with conventional treatments. The methodology employed is comprehensive and appropriate for an initial screening study. The acute toxicity test in Swiss albino mice successfully established a safe dosage range for the methanolic extract, laying a crucial foundation. The evaluation of analgesic effects using both the acetic acid-induced writhing and formalin tests provides robust evidence of pain relief, notably comparable to aspirin. Furthermore, the assessment of anxiolytic properties through a battery of behavioral tests—including open field, cage crossing, rearing, traction, and forced swim tests—yielded promising results, indicating enhanced exploratory behavior and reduced immobility, which intriguingly suggests broader antidepressant-like activity. In conclusion, this research strongly highlights the therapeutic potential of *Perovskia abrotanoides* as a natural remedy for anxiety, depression, and pain, attributing its efficacy to bioactive components that modulate inflammatory pathways and alleviate oxidative stress. While the findings are significant and encouraging, future research should focus on isolating and characterizing the specific bioactive compounds responsible for these effects. Further mechanistic studies to elucidate the exact pathways involved, along with dose-response analyses and comparative studies against standard pharmacological agents, would greatly enhance the translational value of these promising preliminary findings.

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