Andi Eka Yunianto, Sutrio

Hubungan Kadar Asam Urat dengan Kadar Kolesterol HDL pada Peserta Prolanis di Puskesmas Kedaton Bandar Lampung

Introduction

Hubungan kadar asam urat dengan kadar kolesterol hdl pada peserta prolanis di puskesmas kedaton bandar lampung. Studi ini menganalisis hubungan kadar asam urat dan HDL pada peserta Prolanis di Bandar Lampung. Ditemukan korelasi positif, menyoroti peran asam urat dalam metabolisme lipid.

Abstract

ABSTRACT Uric acid and High-Density Lipoprotein (HDL) are important biomarkers associated with the risk of metabolic and cardiovascular diseases. Hyperuricemia is known to increase the risk of hypertension, metabolic syndrome, and heart disease, while low HDL levels contribute to atherosclerosis. However, the relationship between uric acid and HDL levels is still not entirely consistent in various studies. This study aims to analyze the relationship between uric acid and HDL levels in Prolanis patients at the Kedaton Community Health Center, Bandar Lampung. The study used a cross-sectional design involving 42 respondents aged 42–76 years. Data were collected through venous blood examination of 8 ml. HDL levels were measured using the Chod-Pap method, while uric acid levels were measured using the Uricase method. Data analysis used the Pearson test with a significance level of p <0.05. Based on the average HDL level of respondents was 49.79 ± 7.67 mg/dl, while uric acid levels were 7.17 ± 8.13 mg/dl. Correlation analysis showed a significant positive relationship between uric acid levels and HDL (r=0.339; p=0.028). There was a positive relationship between uric acid levels and HDL, indicating that uric acid, at certain levels, may act as an antioxidant that supports lipid metabolism. However, high uric acid levels remain a risk factor for metabolic disease. Further research with larger samples is needed to confirm these findings. ABSTRAK Asam urat dan High-Density Lipoprotein (HDL) merupakan biomarker penting yang berhubungan dengan risiko penyakit metabolik dan kardiovaskular. hiperurisemia diketahui meningkatkan risiko hipertensi, sindrom metabolik, dan penyakit jantung, sementara kadar hdl rendah berkontribusi pada aterosklerosis. namun, hubungan antara kadar asam urat dan HDL masih belum sepenuhnya konsisten dalam berbagai studi. Penelitian ini bertujuan untuk menganalisis hubungan antara kadar asam urat dan kadar HDL pada pasien prolanis di puskesmas kedaton, bandar lampung. Penelitian menggunakan desain potong lintang dengan melibatkan 42 responden berusia 42–76 tahun. data dikumpulkan melalui pemeriksaan darah vena sebanyak 8 ml. kadar hdl diukur dengan metode chod-pap, sedangkan kadar asam urat dengan metode uricase. analisis data menggunakan uji pearson dengan tingkat signifikansi p<0,05. Berdasarkan rata-rata kadar HDL responden adalah 49,79 ± 7,67 mg/dl, sedangkan kadar asam urat 7,17 ± 8,13 mg/dl. analisis korelasi menunjukkan adanya hubungan positif signifikan antara kadar asam urat dan hdl (r=0,339; p=0,028). Terdapat hubungan positif antara kadar asam urat dan HDL, yang mengindikasikan bahwa asam urat pada kadar tertentu mungkin berperan sebagai antioksidan yang mendukung metabolisme lipid. namun, kadar asam urat yang tinggi tetap berisiko terhadap penyakit metabolik. penelitian lanjutan dengan sampel lebih besar diperlukan untuk mengonfirmasi temuan ini.

Review

This study investigates the relationship between uric acid and High-Density Lipoprotein (HDL) levels, two critical biomarkers for metabolic and cardiovascular health. Acknowledging the inconsistent findings in existing literature regarding this relationship, the research aimed to specifically analyze the correlation between these markers in Prolanis patients at the Kedaton Community Health Center in Bandar Lampung. Given that both hyperuricemia and low HDL are established risk factors for various metabolic and cardiovascular conditions, understanding their interplay, particularly in a population predisposed to such issues like Prolanis participants, holds significant clinical relevance. Utilizing a cross-sectional design, the study involved 42 respondents aged 42–76 years. Data were collected via venous blood examination, with HDL levels measured by the Chod-Pap method and uric acid levels by the Uricase method. Statistical analysis employed the Pearson test. The findings indicate an average HDL level of 49.79 ± 7.67 mg/dl and uric acid level of 7.17 ± 8.13 mg/dl among respondents. Most notably, a significant positive correlation was identified between uric acid levels and HDL (r=0.339; p=0.028), suggesting that as uric acid levels increase, HDL levels also tend to increase in this specific patient group. The authors interpret this positive correlation by suggesting that uric acid, at certain levels, might exert an antioxidant effect that supports lipid metabolism. While this hypothesis offers a potential explanation, it is important to balance this with the established knowledge that chronically high uric acid levels are a significant risk factor for adverse metabolic outcomes. The study’s cross-sectional design prevents inferences of causality, and the relatively small sample size (n=42) warrants caution in generalizing these findings. As rightly pointed out by the authors, further research involving larger cohorts and potentially longitudinal designs is essential to confirm these observations and to explore the underlying mechanisms and clinical implications more comprehensively, especially within the context of metabolic management in Prolanis patients.

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