Mufti As Siddiq M. Irzal, Tri Yunis Miko Wahyono, Putri Novia Choiri Insani, Welstin Wemi Loa, Leopardo Alvalius Ngetwa

Association Between Body Mass Index and Mortality in Patients With Tuberculosis-HIV Co-Infection in Asia and Africa

Introduction

Association between body mass index and mortality in patients with tuberculosis-hiv co-infection in asia and africa. Explore the link between Body Mass Index (BMI) and mortality in TB-HIV co-infected patients in Asia & Africa through a systematic review. Identify prognostic factors to inform nutrition interventions.

Abstract

Globally, the prevalence of tuberculosis (TB) and human immunodeficiency virus (HIV) co-infection in 2019 was 8.2%. In 2020, TB-related deaths among individuals with HIV totaled 214,000, representing an increase from the previous year. Previous studies suggest that body mass index (BMI) is a significant predictor of mortality risk in individuals with TB and HIV co-infection, as malnutrition and low BMI are frequently linked to poorer clinical outcomes. This protocol has been developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) guidelines. A systematic review and meta-analysis will be conducted by searching three databases: MEDLINE/PubMed, Scopus, and ProQuest. This protocol aims to outline the stages and procedures of the forthcoming systematic review and meta-analysis, including the justification of the research question; the definition of Population, Exposure, Outcome, and Study design (PEOS); the inclusion and exclusion criteria; the search strategy; study screening and data extraction; and the planned data analysis. Identifying BMI as a prognostic factor through this study may inform nutrition-based interventions and treatment protocols aimed at reducing mortality among individuals co-infected with TB and HIV in Asia and Africa.

Review

This protocol outlines a timely and highly relevant systematic review and meta-analysis addressing the critical public health issue of tuberculosis-HIV co-infection in Asia and Africa. The prevalence and mortality associated with this co-infection remain alarmingly high, underscoring the urgent need to identify modifiable prognostic factors. The focus on Body Mass Index (BMI) as a potential predictor of mortality is well-justified, given the established links between malnutrition, low BMI, and poorer clinical outcomes in these vulnerable populations. By rigorously investigating this association, the forthcoming study has the potential to offer valuable insights that could directly inform clinical practice and public health strategies in high-burden regions. The methodology described in the protocol demonstrates a strong commitment to rigor and transparency. Adherence to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) guidelines is commendable, indicating a meticulous approach to planning the review. The protocol clearly articulates all essential stages, including the justification of the research question, comprehensive definition of Population, Exposure, Outcome, and Study design (PEOS), specific inclusion and exclusion criteria, a robust multi-database search strategy, and detailed plans for study screening, data extraction, and statistical analysis. This thorough outlining of procedures instills confidence that the resultant systematic review will be methodologically sound and produce reliable evidence. Upon completion, this systematic review and meta-analysis promises significant clinical and public health impact. By consolidating existing evidence on the association between BMI and mortality in TB-HIV co-infected patients, particularly within the contexts of Asia and Africa, the study stands to provide a clearer understanding of this prognostic factor. The identification and confirmation of BMI as a key predictor could be instrumental in guiding the development of targeted nutrition-based interventions and refining existing treatment protocols, ultimately aiming to reduce mortality among individuals facing the dual burden of TB and HIV. We eagerly await the full results of this well-conceived and meticulously planned research.

Full Text

Comments

You need to be logged in to post a comment.